By: The Female Catalyst Founders
Molecular glues have emerged as compounds with the potential to revolutionize therapeutic interventions. These molecules are characterized by their unique ability to modulate protein-protein interactions. They have garnered attention for their application in addressing diseases associated with disrupted cellular functions including certain cancers, neurodegenerative disorders, and infectious diseases. Molecular glues have become a more commonly utilized approach for targeted protein degradation offering advantages over traditional small molecule drugs and PROTACS. There have also been reports of molecular glues that stabilize protein-RNA interactions and protein-lipid interactions By influencing specific protein interactions, these compounds offer a novel approach to restoring cellular balance.
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